chom
绝对音准
关于使用rs3057来判定东亚人绝对音准的疑惑
因为我本身是非常确定自己有绝对音准的,但是看到显示的是可能性较小的基因型TT,感到很奇怪于是去查了一下你们这里列出来的参考文献,下面quote:
"Examining data for the Eu families alone, we detected one region, with a maximum LOD score at rs3057 on chromosome 8q24.21 (Figure 1B), that showed strong evidence for linkage, having a nonparametric multipoint exponential LOD score of 3.464 (empirical genome-wide p = .0300)."
"Using the E Asian families, we observed that no linkage peak exceeded the empirical threshold for suggestive linkage (LOD = 1.822), but regions on chromosomes 1, 3, 7, 13, 18 and 19 had linkage peaks with LOD scores greater than 1.0 (Figure 1C and Table 3). Notably, there was no evidence in the E Asian population for linkage in the region of significant linkage (8q24.21) from the Eu sample set. In fact, the chromosome 7 region was the only E Asian region with a LOD score over 1.0 that showed overlap with linkage peaks observed in the Eu data set ."
文里面已经说了8号染色体上的rs3057是对于那些欧洲血统的人有重要关联的,而且还强调说东亚人的linkage根本没证据显示是跟chr. 8q24.21有关,反而是和chr. 1,3,7,13,18,19有关。
WEGENE这里用chr.8上面的rs3057来判定欧洲血统的人可信度是高,但是用来判定我们这些东亚人具有绝对音准的可能性的话....我也只能表示一脸黑人问号...所以说我个人认为这个结果是比较有误导性的。
"Examining data for the Eu families alone, we detected one region, with a maximum LOD score at rs3057 on chromosome 8q24.21 (Figure 1B), that showed strong evidence for linkage, having a nonparametric multipoint exponential LOD score of 3.464 (empirical genome-wide p = .0300)."
"Using the E Asian families, we observed that no linkage peak exceeded the empirical threshold for suggestive linkage (LOD = 1.822), but regions on chromosomes 1, 3, 7, 13, 18 and 19 had linkage peaks with LOD scores greater than 1.0 (Figure 1C and Table 3). Notably, there was no evidence in the E Asian population for linkage in the region of significant linkage (8q24.21) from the Eu sample set. In fact, the chromosome 7 region was the only E Asian region with a LOD score over 1.0 that showed overlap with linkage peaks observed in the Eu data set ."
文里面已经说了8号染色体上的rs3057是对于那些欧洲血统的人有重要关联的,而且还强调说东亚人的linkage根本没证据显示是跟chr. 8q24.21有关,反而是和chr. 1,3,7,13,18,19有关。
WEGENE这里用chr.8上面的rs3057来判定欧洲血统的人可信度是高,但是用来判定我们这些东亚人具有绝对音准的可能性的话....我也只能表示一脸黑人问号...所以说我个人认为这个结果是比较有误导性的。
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@yaoxt
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