到底微基因有没有检测brca1/2变异啊

这研究还在搞呢，BRCA相关的SNP少说有1000多个，而且种族差异很大，不确定东亚人里是否有乳腺癌和宫颈癌的筛查/诊断意义，23andMe报告里只有三个位点，仅适用于德系犹太人。
 
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以下引自23andMe BRCA1/BRCA2 (Selected Variants)报告，供参考：
 
Specific genetic variants in the BRCA1 and BRCA2 genes are associated with an increased risk of developing certain cancers, including breast cancer (in women and men) and ovarian cancer. These variants may also be associated with an increased risk for prostate cancer and certain other cancers. This test includes three genetic variants in the BRCA1 and BRCA2 genes that are most common in people of Ashkenazi Jewish descent.
 
However, more than 1,000 variants in the BRCA1 and BRCA2 genes are known to increase cancer risk, so you could still have a variant not included in this test. In addition, most cases of male breast cancer and prostate cancer are not caused by inherited variants, so men without a variant are still at risk of developing these cancers. It's important to continue with any cancer screenings your healthcare provider recommends.
 
Intended Uses：
Tests for three specific genetic variants: the 185delAG and 5382insC variants in the BRCA1 gene and the 6174delT variant in the BRCA2 gene. These variants are associated with an increased risk of developing certain cancers.
Provides information on whether a person's genetic result is associated with an increased risk for breast and ovarian cancer and may be associated with an increased risk for prostate cancer and certain other cancers.

Limitations
Does not test for all possible variants in the BRCA1 and BRCA2 genes. More than 1,000 variants in these genes are known to increase cancer risk. Only three of those variants are included in this test.
Does not test for variants in other genes linked to hereditary cancers.
Does not account for non-genetic factors, like environment and lifestyle, that influence overall cancer risk.
The interpretation of your genetic result depends on the sex you reported in your account settings.

Important Ethnicities
The variants included in this test are most commonly found in people of Ashkenazi Jewish descent. In 23andMe customers of other ethnicities, between 0% and 0.1% of individuals has one of the three variants in this report.
This test does not include the majority of BRCA1 and BRCA2 variants found in people of other ethnicities. Therefore, a "variants not detected" result is less informative for people with no Ashkenazi Jewish ancestry.
 
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在知道局限性之后，有微解读可以看一下：
https://www.wegene.com/crowdsourcing/details/153
https://www.wegene.com/crowdsourcing/details/152 

 
最后，期待东亚人的研究有进展吧

同问